DOSAGE: greater than 200 mg.
DURATION: unknown.
QUALITATIVE COMMENTS: (with 200 mg) There are the slightest hints of physical response, maybe a smidgin of a lightheadedness at the one hour point. Perhaps a slight teeth clench. Certainly there is no central mental effect.
EXTENSIONS AND COMMENTARY: This particular drug, considering that it was without activity, has proven one of the richest veins of pharmacological raw material. Two clues suggested its potential value. A number of reports in the 150 to 200 milligram area suggested that something was taking place in the periphery even without any clear central effects. The term "body window" was used occasionally by experimenters, an outgrowth of the term "window" that was used (at that time, the mid-1970's) to describe the mental effects of MDMA. It was as if the body was opened up and made receptive, instead of the mind. The second clue came from many anecdotal reports that methedrine (a potent central nervous system stimulant) would augment the effects of an LSD dosage which followed it. The putting of a drug on top of an inactive drug is the "primer" concept. It turned out that MDPR was an extraordinary primer to some following psychedelic, especially LSD, even at modest doses. The putting of a drug on top of an active drug, usually during the latter part of its effectiveness is, as previously stated, called "piggy-backing." A third drug-drug interaction has also been studied; the simultaneous administration of two active drugs, to study synergism. There may be an enhancement, or an inhibition, of one with the other. Let's now re-enter the subsection "Qualitative Comments" again, with this primer concept in mind.
QUALITATIVE COMMENTS: (with 160 mg followed at 2 h by 60 5gs LSD) RThe visual phenomena were extraordinary. We were at the beach just south of Mendocino. In anything that had ever been living, there was an endlessly deep microcosm of detail. Endless, and forever more microscopic in intricacy. A sea urchin shell, a bit of driftwood, a scrap of dried seaweed, each was a treasure of jewels. I have never had such wealth of visual eroticism and bliss before. Later, we visited the pygmy forest, but these living fossils were not as magical.
(with 160 mg followed at 2 h by 60 5gs LSD) RWe both felt the first effects at about 30 minutes, and an hour later we found ourselves in a startling folie-a-deux, involved in reliving the origins of man's arrival on earth. We were deep in a tropic environment, defending ourselves against the nasties of nature (insects, threatening things, blistering heat) and determining that man could indeed live here and perhaps survive. A shared eyes-closed fantasy that seemed to be the same script for both of us.
(with 160 mg followed at 2 h by100 5gs LSD) RThis proved to be almost too intoxicating, and a problem arose that had to have a solution. The entire research group was here, and all were following this same regimen. Two hours into the second half of the experiment a telephone call came that reminded me of a promise I had made to perform in a social afternoon with the viola in a string quartet. Why did I answer the phone? My entire experience was, over the course of about 20 minutes, pushed down to a fragile threshold, and I drove about 10 minutes to attend a swank afternoon event and played an early Beethoven and a middle Mozart with an untouched glass of expensive Merlot in front of me. I could always blame the booze. I declined the magnificent food spread, split, and returned to my own party. Safely home, and given 20 more minutes, I was back into a rolling +++ and I now know that the mind has a remarkable ability to control the particular place the psyche is in.
(with 200 mg followed at 2 h by 60 5gs LSD) RThere was a steady climb from the half-hour point to about 2 hours. There was not the slightest trace of anything sinister. There was simply a super tactile person-to-person window. I had an overpowering urge to go out and interact with other people. To see, to talk, to be with others. There are unending fantasies of things erotic. Perhaps being with others should be circumspect. By evening the effects had largely worn off, but this was an incredible day, beautiful and unexpectedly relaxing.
EXTENSIONS AND COMMENTARY: There is need for more commentary. It must be noted that all of the above comments used rather modest dosages of LSD. The notes of this period, some two years of exploring interactions of the MD series of compounds as preludes to true psychedelics, are difficult to distill into a simple pattern. Most of these studies used LSD in the 60-100 microgram range which is fundamentally a modest level. Many trials were made where the challenge of acid plopped right on top of an active residue of another drug was more in keeping with the "piggyback" argument. An illustration of this is a trial in which the primer was MDMA followed at 5 hours (this is at a time of almost no effect) with a larger dose of LSD (250 micrograms). The LSD overwhelmed the residual numbing of the MDMA, and the generated state was overwhelmingly erotic and out of body. There can be no way of analytically organizing such a gemisch of drug-drug interactions with any logic that would allow a definitive interpretation. And LSD is not the only agent that can be used to challenge the "body window" such as that produced by MDPR. 2C-B, 2C-T-2 and 2C-T-7 have all been used with fine success as well.
In general, the use of an MD compound (looking at it as a stimulant and primer) followed by a psychedelic, brings about an exaggeration and enhancement of the latter compound. Much work must be done in this area to make sense of it all.